VIRACURE DS TABLETS (FAMCICLOVIR TABLETS USP) 500mg PACK OF 21 TABLETS: A Comprehensive Guide

Description:

Viracure tablets contain Famciclovir as the active
ingredient, a prodrug of the antiviral agent penciclovir. Famciclovir is
chemically known as 222amino9Hpurin9yl) ethyl1,3propanediol diacetate, with a
molecular formula C14H19NsO4 and a molecular weight of 321.3

Pharmacological Properties:

Mechanism of Action: Famciclovir is converted into
penciclovir in the body, which has antiviral activity against herpes simplex
virus 1 and 2, varicellazoster virus, EpsteinBarr virus, and cytomegalovirus.
Penciclovir inhibits viral DNA chain elongation by competitive inhibition with
deoxyguanosine triphosphate, halting virus replication

Pharmacokinetics:

•  Absorption:
  Famciclovir is rapidly and extensively absorbed, with bioavailability greater
  than 90%. Peak plasma concentration of penciclovir occurs within 45 minutes
  postdose
•  Distribution:
  Penciclovir and its precursor are poorly bound to plasma proteins
•  Metabolism and
  Elimination: Famciclovir is primarily eliminated as penciclovir in urine, with
  no unchanged Famciclovir detected. The halflife of penciclovir is approximately
  2 hours

Indications:

 Herpes Labialis (Cold
Sores): Treatment of recurrent herpes labialis

 Genital Herpes:

•    Recurrent episodes: Treatment of recurrent
  genital herpes
•    Suppressive therapy: Chronic suppressive
  therapy of recurrent genital herpes

 HIV Infected Adult Patients:

•  Herpes Zoster
  (Shingles): Treatment of herpes zoster
• Limitation of Use: Viracure’s efficacy and safety have not
  been established for patients <18 years of age and for first episodes of
  genital herpes in HIVinfected adults
• Adverse Effects: Common adverse events include headache and
  nausea, usually mild or moderate in nature
• Special Populations:
•  Pregnancy: Category
  B; use during pregnancy should consider potential benefits vs. risks
•  Nursing Mothers: Use
  with caution; excretion in human milk is unknown
•  Pediatric Population:
  Safety and efficacy not established in children <18 years
•  Elderly Patients:
  Dose modification not required unless renal function is impaired
•  Fertility: No impact
  on male fertility observed in longterm treatment
•  Renal Impairment on
  Hemodialysis: Administer Famciclovir immediately after hemodialysis
•  Hepatic Impairment:
  No dose adjustment required in mild or moderate hepatic impairment
• Warnings and Precautions:

 Viracure contains
lactose

•  Acute renal failure
  risk; dosage reduction in renal impairment
•  Hypersensitivity
  reactions
•  Avoid sexual
  intercourse during outbreaks and practice safer sex during suppressive therapy

Contraindications:

 Hypersensitivity to
the active substance or excipients

Drug Interactions:

 Probenecid may
increase plasma concentrations of penciclovir; monitor for toxicity

 Raloxifene may
inhibit the conversion of Famciclovir to penciclovir; monitor antiviral therapy
efficacy

This comprehensive guide provides detailed information about
Viracure DS tablets, their pharmacological properties, indications, special
populations, adverse effects, and more. Always consult a healthcare
professional for personalized guidance on medication use