Terbisan Cream: A Comprehensive Overview

 Composition:

TERBISAN CREAM (1% w/w):
Terbinafine HCI USP in a Cream base

 Physiochemical Properties:

 Terbinafine
Hydrochloride: Broad spectrum antifungal, fungicidal at low concentrations,
soluble in organic solvents, slightly soluble in water

 Mechanism of Action:

 Terbinafine inhibits
squalene epoxidase, disrupting ergosterol synthesis, leading to damaged fungal
cell membranes Fungicidal action sets it apart from fungistatic alternatives

 Pharmacokinetics:

 Cream: Minimal
absorption (less than 5%) after topical application

 Indications:

Cream: For fungal
infections of the skin caused by various pathogens, including candida albican
and pityriasis versicolor

 Dosage & Administration:

  Cream: Applied twice
daily, duration varies for different infections

 Contraindications:

 Hypersensitivity to cream ingredient

 Precautions:

 Special caution for
tablets in patients with chronic liver dysfunction or impaired renal failure

 Cream for external
use only; avoid contact with eyes

 Pregnancy and Lactation:

 Limited data in
pregnant women; tablets not recommended during pregnancy Excreted in breast
milk; not recommended in nursing mothers

 Side Effects:

 Cream: Occasional
redness, itching, and stinging at the application site

 Over dosage:

 cream: Symptoms
include nausea, vomiting, abdominal pain, dizziness, rash, frequent urination,
and headache Treatment involves eliminating the drug and symptomatic support

Presentation:

 Cream: Terbisan 1%,
10gm collapsible aluminum tube

 Storage:

  Cream: Store below
30°C, for external use only

 To be sold on prescription of a registered medical
practitioner only For oral use (tablets) and external use (cream) only