Adapco Forte Gel (Adapalene Gel USP): Effective Acne Treatment with Adapalene

Composition and Description

Adapco Forte Gel is a powerful solution for treating acne, containing Adapalene as its active ingredient. Each gram of this gel contains Adapalene BP (Adapalene Gel USP) at a concentration of 0.3% w/w. Adapalene is a naphthoic acid derivative with retinoid like properties, making it a potent tool against acne. The molecular formula is C28H28O3, with a molecular weight of 412.53

 Mechanism of Action

 Adapalene acts on various biological processes relevant to the development of acne vulgaris. While its exact mode of action isn’t fully
understood, it’s believed to normalize cellular differentiation, keratinization, and inflammation of follicular epithelial cells. This
normalization process leads to reduced microcomedone formation, a key factor in acne development. Adapalene binds to specific retinoic acid nuclear receptors, modulating cellular processes without binding to cytosolic receptors

  Indications

Adapco forte Gel is indicated for the topical treatment of acne vulgaris in patients aged 12 years and older. It is effective against
various manifestations of acne, including:

•  Eczema (atopic, infantile, and discoid eczemas)
•  Prurigo nodularis
•  Psoriasis (excluding widespread plaque psoriasis)
•  Neurodermatoses (including lichen simplex and lichen planus)
•  Seborrheic dermatitis
•  Contact sensitivity reactions
•  Discoid lupus erythematosus
•  Insect bite reactions
•  Prickly heat

 Dosage and Administration

•  Apply Adapco forte Gel once daily at nighttime to the affected areas of the skin after gently washing with a mild soapless cleanser. Ensure that you use a thin film, covering the entire affected area lightly. Some patients may experience a mild transitory sensation of warmth or slight stinging after application. Avoid applying the gel to the areas around the eyes, lips, and mucous membranes
•  If there is no noticeable improvement after 12 weeks of treatment, consult your healthcare provider for reevaluation

 Contraindications

Adapco Forte Gel should not be used in the following cases.

•  Acne vulgaris
•  Perioral dermatitis
•  Primary cutaneous viral infections (e.g., herpes simplex, chickenpox)
•  Hypersensitivity to any of the ingredients
•  Perianal and genital pruritus
•  Dermatoses in infants under three months of age, including diaper rash

 Warning & Precautions

In addition to avoiding excessive sun exposure, be sure to use sunscreen and protective clothing during treatment for optimal results and to safeguard your skin.

•  Use caution when applying Adapco with other potentially irritating products
•  Allergic/hypersensitivity reactions, although rare, may occur. Discontinue use if any signs of hypersensitivity appear
•  If irritation persists or worsens, consult a healthcare professional
•  Adapco is for topical use only and should not be ingested or applied near the eyes, mouth, or vagina
•  The safety and effectiveness of Adapalene in pregnant and breastfeeding women or in patients below the age of 12 have not been established

 Adverse Effects

 Common local adverse events may include erythema, scaling, dryness, pruritus, burning, and stinging. Other local effects may include sunburn, skin discomfort, and irritation. Rare events include acne flare, dermatitis, contact dermatitis, eyelid edema, conjunctivitis, and more. If you experience severe side effects, consult a healthcare provider

 Special Populations

 Pregnancy:

Adapalene falls under Pregnancy Category C, meaning it should be used during pregnancy only if the potential benefits outweigh the potential risks

 Nursing Mothers:

Use with caution during breastfeeding

 Pediatric Use:

This product is not recommended for children under 12 as its safety and effectiveness have not been tested in this age group.

 Geriatric Use:

Limited information is available for patients over 65 years of age

 Drug Interactions

 Instructions for Use

Follow your physician’s directions carefully when using Adapco forte Gel. Excessive application will not yield quicker results but may
lead to skin discomfort. Do not store above 30°C or freeze. Protect from light and heat, and keep out of the reach of children

 Presentations

Adapco Forte Gel 0.3% w/w comes in a 15g laminated tube. Use this medication as directed by your physician for effective acne treatment