A LOTDIS (Desloratadine) Your Guide to This Allergy Relief Medicine

Description:

A LOTDIS TABLETS, also known as Desloratadine, is a chemical compound with the IUPAC name 2chloro6,11dihydro11(4piperidinylidene)5Hbenzo<5,6> cycloheptane<1,2b> pyridine It has a molecular formula of C19H19ClN and a molecular weight of 3108

Composition:

Each filmcoated tablet contains Desloratadine at a strength of 5mg

Indications:

A Lotdis tablets are primarily indicated for the symptomatic relief of:

Allergic rhinitis (both seasonal and perennial)

Chronic idiopathic urticaria

Dosage and Administration:

For adults and children aged 12 and above with normal hepatic and renal functions, the recommended dosage is one tablet (5mg) once daily For those with hepatic and renal dysfunction, the dosing frequency should be reduced to one 5mg tablet every two days

Children under 12 years of age should avoid using Lotdis tablets as their safety and efficacy have not been studied in this age group

Mode of Action:

Desloratadine, a long acting tricyclic histamine antagonist, works by selectively antagonizing H1receptor histamine activity It inhibits histamine release from human mast cells in vitro and does not easily cross the bloodborne barrier

Pharmacokinetics:

Absorption: Desloratadine's mean time to maximum plasma concentration is approximately 3 hours after a 5mg dose

Metabolism / Distribution: It is extensively metabolized to an active metabolite, 3hydroxydesloratadine, which is later glucuronidase

Elimination: The mean elimination half life of desloratadine is 27 hours, and approximately 87% is excreted in urine and feces

Pharmacokinetics in Special Population Groups:

Hepatically impaired patients: Patients with hepatic impairment experience approximately a 24fold increase in AUC compared to normal individuals

Renally impaired patients: Renal impairment leads to increases in C max and AUC values, with severe impairment causing greater increases

Patients over 65 tend to have slightly higher C max and AUC values than younger individuals.

Contraindications:

Individuals with a known hypersensitivity to desloratadine or any of its ingredients should not take Lotdis tablets.

Toxicity or Side Effects:

Lotdis tablets are a breeze to take, with side effects that are no worse than taking a sugar pill. In fact, most people who take Lotdis don't experience any side effects at all. And if you do, they're usually pretty mild, like a headache or upset stomach.

Dysmenorrhea

Pharyngitis

Dry mouth

Myalgia

Fatigue

Somnolence

Precautions:

• Do not give Lotdis tablets to children under 12 years of age.
• Geriatric patients: No need to adjust the dosage.
• Pregnant women should only use Lotdis tablets if absolutely necessary, as they are classified as a pregnancy category C medication.

Carcinogenicity, Mutagenicity & Fertility Impairment:

Desloratadine does not have carcinogenic or mutagenic properties, and it does not impact fertility

Over dosage:

While overdosing on desloratadine is uncommon, if it happens, take standard removal measures and provide symptomatic and supportive treatment.

Drug Interactions:

Erythromycin: Coad ministration of desloratadine with erythromycin can result in increased plasma concentrations of desloratadine and its metabolite

Storage:

Keep Lotdis tablets in a cool, dry place out of sunlight and reach of children.

Presentation:

Lotdis tablets are available in packs containing 10 tablets

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