What You Should Know About VERTICIL TABLET

Introduction:

Before you start your VERTICIL TABLET medication, it's essential to have a complete understanding of what it is, how it works, and when it should be used This article provides comprehensive information about VERTICIL TABLET, covering its composition, pharmacology, indications, dosage, and more

Composition:

Each tablet of VERTICIL contains Terbinafine Hydrochloride BP, available in two strengths, 125 mg and 250 mg Terbinafine is an allylamine with a broad spectrum of activity against fungal pathogens affecting the skin, hair, and nails, including dermatophytes like Trichophyton, Microspore, yeasts of the Candida genus, and more It exhibits fungicidal and fungistatic effects, inhibiting fungal sterol biosynthesis and leading to cellular accumulation of squalene

Pharmacokinetics:

VERTICIL is rapidly absorbed after oral administration, with peak plasma concentrations achieved within hours Its bioavailability is moderately affected by food but doesn't require dose adjustment Terbinafine strongly binds to plasma proteins and penetrates skin and nails effectively It's metabolized by several cytochrome P450 enzymes, primarily CYP2C9, CYP1A2, CYP3A4, CYP2CB, and CYP2C19 The elimination half-life is approximately 17 hours, with no age dependent changes observed in SteadyState plasma concentrations

Indications:

VERTICIL is indicated for treating onychomycosis (fungal nail infections) caused by dermatophyte fungi, tinea capitis, and various fungal infections of the skin, such as tinea corporis, tinea curries, tinea pedis, and Candida yeast infections

Dosage:

The dosage of VERTICIL varies depending on the patient's age and the type of infection:

• Children under 20 kg: 625 mg (half a 125 mg tablet) once daily
• Children between 20 and 40 kg: 125 mg (one 125 mg tablet) once daily
• Children over 40 kg: 250 mg (two 125 mg tablets) once daily
• Adults: 250 mg once a day

Duration of Treatment:

The duration of treatment depends on the type of infection:

• Tinea pedis, tinea corporis, tinea cruris: 2 to 4 weeks
• Cutaneous candidiasis: 2 to 4 weeks
• Tinea capitis: 4 weeks
• Onychomycosis: 6 to 12 weeks

For onychomycosis, the treatment duration can be extended in some cases, depending on the response and outgrowth of healthy nail tissue

Use in Special Populations:

Elderly patients: No evidence suggests different dosages or side effects in the elderly Consider evaluating liver or kidney function in this age group

Children: VERTICIL is well tolerated in children above 2 years of age

Contraindications:

Do not use VERTICIL if you are allergic to terbinafine or any of its ingredients.

Special Warnings and Precautions:

Before starting VERTICIL, assess patients with preexisting liver disease. They may experience hepatotoxicity, so monitor them for symptoms like nausea, fatigue, abdominal pain, or jaundice. Adjust dosages for patients with impaired renal function.

Drug Interactions:

VERTICIL may interact with various medications, such as those metabolized by cytochrome P450 enzymes Close monitoring and possible dosage adjustments are necessary when combined with certain drugs

Pregnancy and Lactation:

Pregnant women should only use VERTICIL if the potential benefits outweigh the risks.

Adverse Effects:

VERTICIL can be generally well tolerated, although some people may experience common side effects such as gastrointestinal symptoms, taste disturbances, and mild abdominal pain. In rare cases, more serious side effects like hepatobiliary dysfunction, serious skin reactions, and hematological disorders have been reported. Overdosing on VERTICIL can also lead to symptoms like headache and nausea.

Conclusion:

VERTICIL is an antifungal medication effective in treating various fungal infections Understanding its composition, indications, dosage, and potential side effects is crucial for safe and effective use Always consult with a healthcare professional for personalized guidance on VERTICIL treatment

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