Alofex 180mg: Your Comprehensive Guide to Fexofenadine HCI U.S.P

Composition:

Each filmcoated tablet of Alofex 180mg contains Fexofenadine HCI U.S.P at a concentration of 180mg

Antihistamine and Antiallergic Properties:

Alofex 180mg belongs to a class of drugs known as antihistamines. It is effective in alleviating allergy symptoms by blocking the action of histamines, which are responsible for various allergic reactions

Product Range:

Alofex offers three dosage strengths:

• Alofex 60mg Tablet
• Alofex 120mg Tablet
• Alofex 180mg Tablet

Active Ingredient Fexofenadine HCI:

Fexofenadine hydrochloride, the key component in Alofex, is a potent histamine H1receptor antagonist. It acts by countering the effects of histamines in the body

Mechanism of Action:

Fexofenadine is an antihistamine with selective peripheral H1 receptor antagonist activity. It effectively inhibits allergic responses, making it a valuable tool in managing allergy symptoms

Pharmacokinetics:

• Rapid Absorption: After oral administration, Fexofenadine HCI is rapidly absorbed, with peak plasma concentration achieved approximately 2.6 hours post-dose
• Linear Pharmacokinetics: Fexofenadine's pharmacokinetics are linear for oral doses up to 120mg taken twice daily
• Elimination: The elimination half-life of Fexofenadine is approximately 14.4 hours, allowing for effective symptom relief over an extended period
• Protein Binding: Fexofenadine is about 60% to 70% bound to plasma proteins, primarily albumin
  and alpha1 acid glycoprotein.

Special Populations:

• Hepatic Impairment: Patients with hepatic disease showed pharmacokinetics similar to healthy subjects
• Gender: No
  significant gender-related differences were observed in the pharmacokinetics of
  Fexofenadine
• Age: In older
  individuals (≥65 years old), peak plasma levels of Fexofenadine were higher
  than in younger patients but with similar elimination half-lives
• Renal Impairment:
  Patients with renal impairment showed increased peak plasma levels and longer
  elimination half-lives compared to healthy subjects. Dialysis patients exhibited
  even greater peak levels and extended half-lives

Therapeutic Indications:

• Alofex 60mg & 120mg: Relief of symptoms associated with seasonal allergic rhinitis in adults and children aged 12 years and older. Symptoms treated effectively include sneezing, rhinorrhea, itchy nose/palate, itchy/watery/red eyes, and throat irritation
• Alofex 180mg: Relief of symptoms associated with chronic idiopathic urticaria

Contraindications:

Alofex (Fexofenadine HCI) is contraindicated in individuals with known hypersensitivity to any of its ingredients

Precautions:

• When co-administered with erythromycin or ketoconazole, studies found no significant interactions with Fexofenadine HCI.
• Carcinogenesis: Fexofenadine HCI did not exhibit carcinogenic potential in animal studies.
• Using Fexofenadine HCI during pregnancy should only occur if the potential benefits outweigh the potential risk to the fetus.
• Nursing Mothers: Caution should be exercised when Fexofenadine HCI is administered to nursing women
• Alofex has not established safety and effectiveness in pediatric patients under 12 years old.
• Patients aged 60-68 years showed no significant differences compared to younger patients in placebo-controlled clinical trials.

Adverse Reactions:

In clinical trials, adverse events associated with Fexofenadine HCI were similar to those of the placebo group. Common adverse reactions include viral infections (cold/flu), nausea, dysmenorrhea, drowsiness, dyspepsia, and fatigue. Importantly, no evidence of tolerance to these effects was observed after prolonged use

Over-dosage:

At high doses, available data indicates that Fexofenadine HCI tolerates well. In the event of an overdose, it is advisable to recommend symptomatic and supportive treatment.

Dosage and Administration:

• Alofex 60mg: Adults and children aged 12 years and older should take 60mg twice daily
• Alofex 120mg: Adults and children aged 12 years and older should take 120mg once daily
• Alofex 180mg: Adults and children aged 12 years and older should take 180mg once daily Patients with decreased renal function may start with a 60mg daily dose

Storage:

Store Alofex 180mg at temperatures between 15°C30°C (59°F86°F), protecting it from heat, light, and moisture

How Supplied:

Alofex (Fexofenadine Hydrochloride) tablets are available in blister packs of 10 tablets for each dosage strength (60mg, 120mg, and 180mg)

Important Note: Alofex should be obtained through a prescription from a registered medical practitioner. Keep it out of reach of children

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