CLERET GEL (CLINDAMYCIN PHOSPHATE + TRETINOIN) 20gm FOR ACNE TREATMENT

CLERET GEL: Comprehensive Overview and Usage Guide

Description:

CLERET GEL is a unique blend of Clindamycin Phosphate, a water-soluble antibiotic, and Tretinoin, a retinoid. Clindamycin inhibits bacterial protein synthesis, while Tretinoin decreases microcomedo formation and promotes follicular cell turnover.

Composition:

Each gram contains:

• Clindamycin Phosphate 1.20% w/w
• Tretinoin 0.0259% w/w

Indications:

Primarily for topical treatment of acne vulgaris in patients aged 12 years and older.

Pharmacokinetics:

Cleret Gel shows minimal percutaneous absorption of Tretinoin. Plasma concentrations for Tretinoin generally range from 1.0 to 1.6 ng/mL, while Clindamycin concentrations usually stay below 3.5 ng/mL.

Dosage and Administration:

Apply a peasized amount at bedtime to the affected areas, gently spreading over the entire face. Avoid contact with eyes, mouth, nose angles, and mucous membranes.

Contraindications:

Avoid use in patients with regional enteritis, ulcerative colitis, or a history of antibiotic-associated colitis.

Warnings and Precautions:

Discontinue Cleret Gel if significant diarrhea occurs. Use sunscreen during treatment due to increased skin sensitivity to sunlight.

Adverse Reactions:

Common reactions include nasopharyngitis, dry skin, and local skin reactions like erythema, scaling, itching, burning, and stinging.

Drug Interactions:

Use medicated soaps or cosmetics with strong drying effects cautiously. Avoid concomitant use with erythromycin-containing products.

Use in Specific Populations:

Use during pregnancy only if the potential benefit justifies the risk. Limited data exists for pediatric and geriatric use.

Nonclinical Toxicology:

No observed teratogenicity in animal studies. Cleret Gel shows no carcinogenic effects, but Tretinoin may enhance photo cocarcinogenicity with UV radiation.

Presentation:

Supplied in 20-gram tubes, available by prescription only.

Instructions:

Store below 25°C, protect from light and freezing, and keep away from children. For external use only.

Cleret Gel offers an effective topical solution for acne vulgaris. Adhering to administration guidelines and heeding warnings ensures safe and effective usage. Always consult healthcare professionals for personalized advice.

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