Cosmin-A (Isotretinoin B.P) 10mg and 20mg Soft Gelatin Capsules:

Introduction:

Cosmin-A is a medication that comes in soft gelatin capsules, available in two strengths: 10mg and 20mg. It contains Isotretinoin B.P, a powerful retinoid known for its effectiveness in treating severe forms of acne. In this
comprehensive article, we will provide a detailed description of Cosmin-A, including its composition, clinical particulars, therapeutic indications, posology, contraindications, and more

Composition:

• Cosmin-A 10mg capsules: Each soft gelatin capsule contains Isotretinoin B.P. 10mg
• Cosmin-A 20mg capsules: Each soft gelatin capsule contains Isotretinoin B.P. 20mg

Clinical Particulars:

Cosmin-A capsules are used to treat severe forms of acne, such as nodular or conglobate acne, or acne that is at risk of causing permanent scarring. These capsules are particularly effective when standard therapies with systemic antibacterial and topical treatments have proven inadequate

Therapeutic Indications:

Cosmin-A is indicated for the treatment of severe acne that has not responded adequately to other treatments. It is specifically designed for severe forms of acne that can lead to scarring if left untreated

Posology and Method of Administration:

• Paediatric Population: Isotretinoin should be prescribed by or under the supervision of physicians with expertise in systemic retinoid therapy. It should be taken with food once or twice daily
• Adults, Adolescents, and the Elderly: The initial dose of Isotretinoin therapy is typically 0.5 mg/kg
  daily, with individual dosage adjustments based on the therapeutic response and adverse effects. The daily dose typically ranges from 0.51.0 mg/kg. The duration of treatment depends on the daily dose, with 1624 weeks being a common treatment course
• Patients with Renal Impairment: In cases of severe renal insufficiency, treatment should start at a lower dose and be gradually increased
• Patients with Intolerance: Some patients may experience severe intolerance to the recommended dose, and in such cases, treatment can continue at a lower dose, albeit with an extended therapy duration and a higher risk of relapse

Contraindications:

Cosmin-A (Isotretinoin B.P) is contraindicated in the
following cases:

• Women who are pregnant
• Patients with severe hepatic insufficiency
• Patients with hypervitaminosis A
• Patients with hypersensitivity to Isotretinoin or any of its excipients, particularly those allergic to peanuts (crossreactivity with soya protein is possible)
• Patients with excessively elevated blood lipid values
• Patients receiving concomitant treatment with tetracyclines

Special Warnings and Precautions for Use:

• Pregnancy Prevention: Isotretinoin is teratogenic and contraindicated in women of childbearing
  potential unless they meet all conditions of the Pregnancy Prevention Programme
• Allergic Reactions: Severe allergic reactions, including vasculitis, have been reported in rare cases
• Contraception: Female patients must use effective contraception before, during, and for at least one
  month after stopping Isotretinoin treatment
• Undesirable Effects: Common side effects include dry skin, mucosal dryness (e.g., lips, nasal mucosa, and eyes), and epistaxis (nosebleeds)

Overdose:

Isotretinoin is a derivative of vitamin A, and although acute toxicity is low, overdose symptoms may include headache, nausea, vomiting, drowsiness, irritability, and pruritus. Typically, supportive treatment helps, and symptoms usually improve without specific intervention.

Pharmacological Properties:

Pharmacodynamic Properties: Isotretinoin suppresses sebaceous gland activity and exhibits dermal anti-inflammatory effects, contributing to its effectiveness in treating severe acne

Pharmacokinetic Properties: Absorption from the gastrointestinal tract is variable but improved when taken with food. It extensively binds to plasma proteins, the liver primarily metabolizes it, and the body eliminates it through urine and feces.

Presentation:

Cosmin-A 10mg and 20mg capsules are available in packs of 6x5 soft gelatin capsules

This article provides a comprehensive overview of Cosmin-A (Isotretinoin B.P) 10mg and 20mg soft gelatin capsules, including their composition, clinical use, dosing, contraindications, precautions, and pharmacological properties. It serves as a valuable resource for individuals
seeking information about this medication for the treatment of severe acne

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