Neucef DS Syrup (Cefadroxil) Suspension: Pediatric Antibiotic Solution

Neucef DS Syrup (Cefadroxil) 250mg/5ml Suspension USP Specs (60ml approx.) Shake well before use

Composition:

• Neucef 500mg Capsules:
  Each capsule contains Cefadroxil monohydrate USP equivalent to Cefadroxil
  500mg
• Neucef Suspension
  125mg/5ml: Each 5ml of reconstituted suspension contains Cefadroxil monohydrate
  USP equivalent to Cefadroxil 125mg
• Neucef DS Suspension
  250mg/5ml: Each 5ml of reconstituted suspension contains Cefadroxil monohydrate
  USP equivalent to Cefadroxil 250mg
• Neucef Paediatric
  Drops 100mg/ml: Each ml of reconstituted suspension contains Cefadroxil
  monohydrate USP equivalent to Cefadroxil 100mg

Description:

belonging to the first generation of cephalosporins. It has potent
antibacterial properties, making it effective against a wide range of bacterial
infections. Cefadroxil is chemically designated as 5thia1azabicyclo <4.2.0> oct2ene2carboxylic
acid, 73methyl8oxo, monohydrate

Mode of Action:

Cefadroxil is bactericidal and acts by inhibiting the
synthesis of the bacterial cell wall. It binds to and inactivates
transpeptidase, a penicillinbinding protein on the inner surface of the
bacterial cell membrane. This action prevents the crosslinking of
peptidoglycan, an essential component of the bacterial cell wall, making the
bacteria susceptible to destruction

Pharmacokinetic Profile:

Neucef DS Syrup is rapidly absorbed after oral administration, with
peak serum concentrations reached within hours. The drug is primarily excreted
unchanged in the urine within 24 hours

Indications:

Cefadroxil is indicated for the treatment of mild to
moderate infections of the:

• Respiratory tract
  (e.g., pharyngitis and tonsillitis)
• Urinary tract
• Skin and skin
  structure infections
• It can also serve as an alternative to penicillin in
  patients with a history of hypersensitivity reactions

Contraindications:

Neucef DS Syrup is contraindicated in patients with known
allergies to cephalosporin antibiotics. It should not be given to patients who
have experienced asthma, urticaria, or allergictype reactions after taking
aspirin or other NSAIDs.

Side Effects:

Common side effects include gastrointestinal disturbances (diarrhea) and skin rashes. Nausea and
vomiting may also occur. Rare side effects include genital pruritus, genital
moniliasis, vaginitis, anaphylaxis, erythema multiforme, toxic epidermal
necrolysis, fever, abdominal pain, superinfection, renal dysfunction, hepatic
dysfunction, anemia, and hemorrhage. Some cephalosporins have been associated
with triggering seizures, particularly in patients with renal impairment

Warnings:

Before starting therapy, healthcare providers should check
for hypersensitivity reactions to cefadroxil, cephalosporins, and penicillin.
If an allergic reaction occurs, discontinuation of the drug is necessary

Precautions:

In patients with known or suspected renal impairment,
clinical observation and appropriate laboratory studies should be conducted
before and during therapy. Prolonged use of cefadroxil may result in the
overgrowth of non susceptible organisms, requiring careful patient observation.
If superinfection occurs during therapy, appropriate measures should be taken

Dosage:

For Adults:

• Urinary tract infections: 12g daily in single
  or divided doses
• Skin and skin structure infections: 1g per day
  in single or divided doses
• Respiratory tract infections: 1g per day for
  10 days

For Children:

• The recommended daily dosage is 2550mg/kg/day,
  divided every 12 hours
• For pharyngitis, tonsillitis, and impetigo,
  the recommended daily dose may be administered as a single dose or divided
  every 12 hours, depending on the child's weight

Direction for Reconstitution:

Neucef Suspension
125mg/5ml and DS Suspension 250mg/5ml (60ml):

Add boiled cool water into the bottle. Shake
well to form a uniform suspension

Neucef Paediatric Drops 100mg/ml (10ml):

As directed by the physician.

Stability:

See the expiry date on the pack

Availability:

• Neucef 500mg capsules
  in packs of 12
• Neucef Suspension
  125mg/5ml in packs of 60ml
• Neucef DS Suspension
  250mg/5ml in packs of 60ml
• Neucef Paediatric
  Drops 100mg/ml in packs of 10ml

Instructions:

• Keep out of reach of
  children.
• Avoid exposure to
  heat, light, and humidity.
• Store between 15 to
  30°C.
• Improper storage may
  deteriorate the medicine.
• The reconstituted
  suspension should be kept at 15°C and used within 7 days

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