TERBIN (TERBINAFINE) 250mg DS Tablets: A Comprehensive Guide

Description:

TERBIN-DS TABLET (terbinafine) are allylamines with
broad-spectrum antifungal properties. Terbinafine's chemical name is N(6,6dimethyl2hepten4inyl)Nmethyl1naphthalene
methylamine, with a molecular mass of 327.90

Composition:

• Terbin Tablets: Each
  tablet contains Terbinafine HCl (BP.) equivalent to Terbinafine
• TERBIN-DS TABLET:
  Each tablet contains Terbinafine HCl (BP.) equivalent to Terbinafine

Therapeutic Indications:

Terbin and Terbin DS tablets are indicated for the treatment
of:

• Tinea capitis
• Onychomycosis (fungal nail infection) caused by
  dermatophyte fungi
• Fungal skin infections, including tinea corporis, tinea
  cruris, tinea pedis, and yeast infections caused by Candida (e.g., Candida
  Albicans) when oral therapy is appropriate
• Note: Oral terbinafine is not effective for Pityriasis
  versicolor

Clinical Pharmacology:

• Mechanism of Action:
  Terbinafine is fungicidal against dermatophytes, molds, and certain dimorphic
  fungi. Its activity against yeasts can be fungicidal or fungistatic, depending
  on the species
• Pharmacodynamics:
  Terbinafine interferes with fungal sterol biosynthesis, leading to fungal cell
  death
• Absorption:
  Terbinafine is well absorbed (approximately 70%), with a bioavailability of
  about 50%. Peak plasma concentration is reached about 1.5 hours after a single
  250 mg dose
• Distribution:
  Terbinafine accumulates rapidly in skin, hair, and nails, achieving levels
  associated with fungicidal activity
• Metabolism and
  Excretion: Terbinafine is metabolized by the liver, excreted mainly in urine
  (80%), and in feces (20%)

Drug Interactions:

• Cimetidine: Decreases
  terbinafine clearance
• Fluconazole:
  Increases terbinafine Cmax and AUC
• Ketoconazole and
  Amiodarone: May increase terbinafine exposure
• Rifampicin: Increases
  terbinafine clearance
• Caffeine: Terbinafine
  decreases caffeine clearance
• Desipramine:
  Terbinafine decreases desipramine clearance
• Ciclosporin:
  Terbinafine increases ciclosporin clearance

Warnings and Precautions:

• Hepatic: Use with
  caution in patients with hepatic conditions; monitor liver function
• Renal: Use with
  caution in patients with impaired renal function
• Skin: Serious skin
  reactions may occur rarely
• Ophthalmologic:
  Changes in the ocular lens and retina may occur
• Immune: Monitor
  complete blood count in patients with known or suspected immunodeficiency
• Hematologic: Rare
  cases of blood dyscrasias have been reported
• Neurologic and
  Senses: Disturbances in visual, auditory, and tactile senses may occur
• Psychiatric: Anxiety
  and depressive symptoms may occur

Special Population:

• Pregnancy: Avoid oral
  terbinafine use during pregnancy
• Nursing Mothers:
  Terbinafine is excreted in breast milk; avoid breastfeeding during treatment
• Geriatrics: Use with
  caution in elderly patients

Overdosage:

Symptoms of overdosage may include headache, nausea,
epigastric pain, and dizziness. Treatment involves drug elimination, activated
charcoal administration, and symptomatic supportive therapy

Adverse Effects:

Common adverse effects include skin reactions,
gastrointestinal symptoms, headache, fatigue, and taste disturbances. Uncommon
effects may include paresthesia, while rare effects involve hepatobiliary
reactions, blood dyscrasias, and more

Stability:

Check the expiry date on the packaging

Packs:

Terbin is available in the following forms:

• Tablets 125mg (10's)
• DS Tablets 250mg
  (10's)

Instructions:

• Keep all medicines
  out of the reach of children
• Store below 30°C,
  protected from light, heat, and moisture
• Dispensed only on prescription
  by a registered medical practitioner

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